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Article Dans Une Revue Neurology Année : 2021

Spectrum of Clinical Features in X-Linked Myotubular Myopathy Carriers: An International Questionnaire Study

Stacha F. I. Reumers
  • Fonction : Auteur
Frederik Braun
  • Fonction : Auteur
Jennifer E. Spillane
  • Fonction : Auteur
Maartje Pennings
  • Fonction : Auteur
Meyke Schouten
  • Fonction : Auteur
Anneke J. van der Kooi
  • Fonction : Auteur
A. Reghan Foley
  • Fonction : Auteur
Carsten G. Bonnemann
  • Fonction : Auteur
Erik-Jan Kamsteeg
  • Fonction : Auteur
Corrie E. Erasmus
  • Fonction : Auteur
Ulrike Schara-Schmidt
  • Fonction : Auteur
Heinz Jungbluth
  • Fonction : Auteur
Nicol C. Voermans
  • Fonction : Auteur

Résumé

OBJECTIVE: To characterize the spectrum of clinical features in a cohort of X-linked myotubular myopathy (XL-MTM) carriers, including prevalence, genetic features, clinical symptoms, and signs, as well as associated disease burden. METHODS: We performed a cross-sectional online questionnaire study among XL-MTM carriers. Participants were recruited from patient associations, medical centers, and registries in the United Kingdom, Germany, and the Netherlands. We used a custom-made questionnaire, the Checklist Individual Strength (CIS), the Frenchay Activities Index (FAI), the Short Form 12 (SF-12) health survey, and the McGill Pain Questionnaire. Carriers were classified as manifesting or nonmanifesting on the basis of self-reported ambulation and muscle weakness. RESULTS: The prevalence of manifesting carriers in this study population (n = 76) was 51%, subdivided into mild (independent ambulation, 39%), moderate (assisted ambulation, 9%), and severe (wheelchair dependent, 3%) phenotypes. In addition to muscle weakness, manifesting carriers frequently reported fatigue (70%) and exercise intolerance (49%). Manifesting carriers scored higher on the overall CIS (p = 0.001), the fatigue subscale (p < 0.001), and least severe pain subscale (p = 0.005) than nonmanifesting carriers. They scored lower on the FAI (p = 0.005) and the physical component of the SF-12 health survey (p < 0.001). CONCLUSIONS: The prevalence of manifesting XL-MTM carriers may be higher than currently assumed, most having a mild phenotype and a wide variety of symptoms. Manifesting carriers are particularly affected by fatigue, limitations of daily activities, pain, and reduced quality of life. Our findings should increase awareness and provide useful information for health care providers and future clinical trials.

Dates et versions

hal-03714795 , version 1 (05-07-2022)

Identifiants

Citer

Stacha F. I. Reumers, Frederik Braun, Jennifer E. Spillane, Johann Böhm, Maartje Pennings, et al.. Spectrum of Clinical Features in X-Linked Myotubular Myopathy Carriers: An International Questionnaire Study. Neurology, 2021, 97 (5), ⟨10.1212/WNL.0000000000012236⟩. ⟨hal-03714795⟩
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