Bola‐Amphiphilic Glycodendrimers: New Carbohydrate Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Chemistry - A European Journal Année : 2022

Bola‐Amphiphilic Glycodendrimers: New Carbohydrate Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins

Résumé

Dendrimers are appealing scaffolds for creating carbohydrate mimics with unique multivalent cooperativity. We report here novel bola-amphiphilic glycodendrimers bearing mannose and glucose terminals, and a hydrophobic thioacetal core responsive to reactive oxygen species. The peculiar bola- amphiphilic feature enabled stronger binding to lectin compared to the conventional amphiphile. In addition, these dendrimers are able to target mannose receptors and glucose transporters expressed at the surface of cells, allowing effective and specific cellular uptake. This highlights their great promise for targeted delivery.
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Dates et versions

hal-03725167 , version 1 (15-07-2022)

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Citer

Wenzheng Zhang, Dinesh Dhumal, Xiaolei Zhu, Brigino Ralahy, Aleksandra Ellert-Miklaszewska, et al.. Bola‐Amphiphilic Glycodendrimers: New Carbohydrate Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins. Chemistry - A European Journal, inPress, ⟨10.1002/chem.202201400⟩. ⟨hal-03725167⟩
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