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Article Dans Une Revue EMBO Reports Année : 2012

Hairless promotes PPARγ expression and is required for white adipogenesis

Résumé

Adipose tissue is the largest compartment in the mammalian body for storing energy as fat, providing an important reservoir of fuel for maintaining whole body energy homeostasis. Herein, we identify the transcriptional cofactor hairless (HR) to be required for white adipogenesis. Moreover, forced expression of HR in non-adipogenic precursor cells induces adipogenic gene expression and enhances adipocyte formation under permissive conditions. HR exerts its proadipogenic effects by regulating the expression of PPARγ, one of the central adipogenic transcription factors. In conclusion, our data provide a new mechanism required for white adipogenesis.

Dates et versions

hal-03744134 , version 1 (02-08-2022)

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Susann Kumpf, Michael Mihlan, Alexander Goginashvili, Gerald Grandl, Helmuth Gehart, et al.. Hairless promotes PPARγ expression and is required for white adipogenesis. EMBO Reports, 2012, 13 (11), pp.1012-1020. ⟨10.1038/embor.2012.133⟩. ⟨hal-03744134⟩
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