%0 Journal Article %T Identification of Modulators of the C. elegans Aryl Hydrocarbon Receptor and Characterization of Transcriptomic and Metabolic AhR-1 Profiles %+ Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124) %+ Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601) %+ Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)) %+ Laboratoire sur les interactions Epithéliums Neurones (LIEN) %+ Service de biochimie métabolique [CHU Necker] %+ Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)) %+ Génomique fonctionnelle des tumeurs solides = Functional Genomics of Solid Tumors [CRC] (FunGeST) %+ Centre de RMN à très hauts champs de Lyon (CRMN) %+ Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB) %+ Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing (B2A) %+ Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf] %+ Biomedtech Facilities (UMS 2009 / US36) %A Larigot, Lucie %A Bui, Linh-Chi %A de Bouvier, Marine %A Pierre, Ophélie %A Pinon, Grégory %A Fiocca, Justine %A Ozeir, Mohammad %A Tourette, Cendrine %A Ottolenghi, Chris %A Imbeaud, Sandrine %A Pontoizeau, Clément %A Blaise, Benjamin, J %A Chevallier, Aline %A Tomkiewicz, Céline %A Legrand, Béatrice %A Elena-Herrmann, Bénédicte %A Néri, Christian %A Brinkmann, Vanessa %A Nioche, Pierre %A Barouki, Robert %A Ventura, Natascia %A Dairou, Julien %A Coumoul, Xavier %< avec comité de lecture %@ 2076-3921 %J Antioxidants %I MDPI %V 11 %N 5 %P 1030 %8 2022-05-23 %D 2022 %R 10.3390/antiox11051030 %M 35624894 %K Aryl hydrocarbon Receptor %K Caenorhabditis elegans %K transcriptomics %K metabolomics %K modulators %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN] %Z Life Sciences [q-bio]/Animal biology/Invertebrate Zoology %Z Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] %Z Life Sciences [q-bio]/ToxicologyJournal articles %X The Aryl hydrocarbon Receptor (AhR) is a xenobiotic sensor in vertebrates, regulating the metabolism of its own ligands. However, no ligand has been identified to date for any AhR in invertebrates. In C. elegans, the AhR ortholog, AHR-1, displays physiological functions. Therefore, we compared the transcriptomic and metabolic profiles of worms expressing AHR-1 or not and investigated the putative panel of chemical AHR-1 modulators. The metabolomic profiling indicated a role for AHR-1 in amino acids, carbohydrates, and fatty acids metabolism. The transcriptional profiling in neurons expressing AHR-1, identified 95 down-regulated genes and 76 up-regulated genes associated with neuronal and metabolic functions in the nervous system. A gene reporter system allowed us to identify several AHR-1 modulators including bacterial, dietary, or environmental compounds. These results shed new light on the biological functions of AHR-1 in C. elegans and perspectives on the evolution of the AhR functions across specie %G English %2 https://hal.science/hal-03745310/document %2 https://hal.science/hal-03745310/file/antioxidants-11-01030-v2.pdf %L hal-03745310 %U https://hal.science/hal-03745310 %~ INSERM %~ ENS-LYON %~ UNIV-BREST %~ EPHE %~ UGA %~ CNRS %~ UNIV-LYON1 %~ APHP %~ CORDELIERS %~ B2A %~ INC-CNRS %~ PSL %~ IBPS %~ LIEN %~ CHU-UNIV-PARIS5 %~ SORBONNE-UNIVERSITE %~ SORBONNE-UNIV %~ IBSAM %~ SU-SCIENCES %~ TEST-DEV %~ UDL %~ UNIV-LYON %~ UNIV-PARIS %~ UNIVERSITE-PARIS %~ UP-SANTE %~ UP-SCIENCES %~ EPHE-PSL %~ BFA %~ UGA-EPE %~ SU-TI %~ ALLIANCE-SU %~ TEST2-HALCNRS