Plasticity of natural killer cells in pregnant patients infected with SARS-CoV-2 and their neonates during childbirth - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Frontiers in Immunology Année : 2022

Plasticity of natural killer cells in pregnant patients infected with SARS-CoV-2 and their neonates during childbirth

Résumé

The COVID-19 pandemic has occurred due to infection caused by the SARS-CoV-2 coronavirus, which impacts gestation and pregnancy. In SARS-CoV-2 infection, only very rare cases of vertical transmission have been reported, suggesting that fetal immune imprinting due to a maternal infection is probably a result of changes in maternal immunity. Natural killer (NK) cells are the leading maternal immune cells that act as a natural defense system to fight infections. They also play a pivotal role in the establishment and maintenance of pregnancy. While peripheral NK cells display specific features in patients infected with SARS-CoV-2 in the general population, information remains elusive in pregnant mothers and neonates. In the present study, we analyzed the characteristics of NK cells isolated from both neonatal umbilical cord blood and maternal peripheral blood close to the time of delivery. Phenotype and functions were compared in 18 healthy pregnant women and 34 COVID-19 patients during pregnancy within an ongoing infection (PCR + ; N = 15) or after recovery (IgG + PCR − ; N = 19). The frequency of NK cells from infected women and their neonates was correlated with the production of inflammatory cytokines in the serum. The expression of NKG2A and NKp30, as well as degranulation of NK cells in pregnant women with ongoing infection, were both negatively correlated to estradiol level. Furthermore, NK cells from the neonates born to infected women were significantly decreased and also correlated to estradiol level. This study highlights the relationship between NK cells, inflammation, and estradiol in patients with ongoing infection, providing new insights into the impact of maternal SARS-CoV-2 infection on the neonate.
Fichier principal
Vignette du fichier
fimmu-13-893450.pdf (2.73 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03745730 , version 1 (31-10-2022)

Licence

Paternité

Identifiants

Citer

Marie Carbonnel, Camille Daclin, Nadine Tarantino, Olivia Groiseau, Véronique Morin, et al.. Plasticity of natural killer cells in pregnant patients infected with SARS-CoV-2 and their neonates during childbirth. Frontiers in Immunology, 2022, 13, pp.893450. ⟨10.3389/fimmu.2022.893450⟩. ⟨hal-03745730⟩
91 Consultations
36 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More