%0 Journal Article %T Parallel reduction in flowering time from de novo mutations enable evolutionary rescue in colonizing lineages %+ Max Planck Society (GERMANY) %+ University of Vienna [Vienna] %+ Max F. Perutz Laboratories %+ Vienna Grad Sch Populat Genet %+ Parque Nat Fogo %+ Associação Projecto Vitó %+ Universität Heidelberg [Heidelberg] %+ Biosystematics Group, Wageningen University and Research %+ Laboratoire des Interactions Plantes Microbes Environnement (LIPME) %+ Mathematics and BioSciences Group %A Fulgione, Andrea %A Neto, Célia %A Elfarargi, Ahmed %A Tergemina, Emmanuel %A Ansari, Shifa %A Göktay, Mehmet %A Dinis, Herculano %A Döring, Nina %A Flood, Pádraic %A Rodriguez-Pacheco, Sofia %A Walden, Nora %A Koch, Marcus %A Roux, Fabrice %A Hermisson, Joachim %A Hancock, Angela %Z Marie Curie CIG : 304301 %Z National Science Foundation (NSF) 1064766 %Z Max Planck Society Funding %Z Austrian Science Fund (FWF) : DK W1225-B20 %Z German Research Foundation (DFG)European CommissionFOR 1078 %< avec comité de lecture %@ 2041-1723 %J Nature Communications %I Nature Publishing Group %V 13 %N 1 %P 14 p. %8 2022-12 %D 2022 %R 10.1038/s41467-022-28800-z %M 35304466 %Z Life Sciences [q-bio]/Vegetal Biology %Z Life Sciences [q-bio]/Genetics/Plants geneticsJournal articles %X Abstract Understanding how populations adapt to abrupt environmental change is necessary to predict responses to future challenges, but identifying specific adaptive variants, quantifying their responses to selection and reconstructing their detailed histories is challenging in natural populations. Here, we use Arabidopsis from the Cape Verde Islands as a model to investigate the mechanisms of adaptation after a sudden shift to a more arid climate. We find genome-wide evidence of adaptation after a multivariate change in selection pressures. In particular, time to flowering is reduced in parallel across islands, substantially increasing fitness. This change is mediated by convergent de novo loss of function of two core flowering time genes: FRI on one island and FLC on the other. Evolutionary reconstructions reveal a case where expansion of the new populations coincided with the emergence and proliferation of these variants, consistent with models of rapid adaptation and evolutionary rescue. %G English %2 https://hal.inrae.fr/hal-03748172/document %2 https://hal.inrae.fr/hal-03748172/file/Fulgione-NP-2022.pdf %L hal-03748172 %U https://hal.inrae.fr/hal-03748172 %~ CNRS %~ OPENAIRE %~ INRAE %~ ANR %~ INRAEOCCITANIETOULOUSE %~ LIPME %~ RESEAU-EAU