Alkaline phosphatase multi-tasks in the brain - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Poster De Conférence Année : 2018

Alkaline phosphatase multi-tasks in the brain

C Fonta
Marie Gleizes
  • Fonction : Auteur
  • PersonId : 1150608
C Préhaud
Lionel G. Nowak

Résumé

Introduction: There are several genes for alkaline phosphatase (AP). One of them codes for TNAP (Tissue Non-specific Alkaline Phosphatase). It is a ubiquitous ectoenzyme located in different tissues in the body. In the brain, this enzyme is GPI anchored on the neuronal membrane, especially on node of Ranvier and synapses (Fonta et al., 2005). Mutations of the TNAP gene are responsible for hypophosphatasia, a rare disease characterized by defective bone mineralization (Millan, 2006) caused by pyrophosphate accumulation. In the severe form, hypophosphatasia is associated with epileptic seizures (Whyte, 1995). This neurological disorder could be explained by a decrease in GABA level due to lack of pyridoxal 5’phosphate (PLP) dephosphorylation
Fichier principal
Vignette du fichier
posterfinal_corrige.pdf (1.86 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03781657 , version 1 (20-09-2022)

Identifiants

  • HAL Id : hal-03781657 , version 1

Citer

C Fonta, Marie Gleizes, Anne Briolay, Thomas Cruz, C Préhaud, et al.. Alkaline phosphatase multi-tasks in the brain. 11th Forum of European Neuroscience Societies (FENS 2018), Jul 2018, Berlin, Germany. ⟨hal-03781657⟩
34 Consultations
6 Téléchargements

Partager

Gmail Facebook X LinkedIn More