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Article Dans Une Revue Neural Regeneration Research Année : 2023

Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson’s disease

Résumé

By controlling the proper folding of proteins imported into mitochondria and ensuring crosstalk between the reticulum and mitochondria to modulate intracellular calcium fluxes, Mortalin is a chaperone protein that plays crucial roles in neuronal homeostasis and activity. However, its expression and stability are strongly modified in response to cellular stresses, in particular upon altered oxidative conditions during neurodegeneration. Here, we report and discuss the abundant literature that has highlighted its contribution to the pathophysiology of Parkinson’s disease, as well as its therapeutic and prognostic potential in this still incurable pathology.
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Dates et versions

hal-03795538 , version 1 (14-02-2023)

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Paternité

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Baptiste Texier, Morgane Prime, Djamaa Atamena, Pascale Belenguer, Marion Szelechowski. Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson’s disease. Neural Regeneration Research, 2023, 18 (2), pp.293-298. ⟨10.4103/1673-5374.346487⟩. ⟨hal-03795538⟩
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