2D Zn‐Porphyrin‐Based Co(II)‐MOF with 2‐Methylimidazole Sitting Axially on the Paddle–Wheel Units: An Efficient Electrochemiluminescence Bioassay for SARS‐CoV‐2 - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Advanced Functional Materials Année : 2022

2D Zn‐Porphyrin‐Based Co(II)‐MOF with 2‐Methylimidazole Sitting Axially on the Paddle–Wheel Units: An Efficient Electrochemiluminescence Bioassay for SARS‐CoV‐2

Yi‐xuan Li
  • Fonction : Auteur
Jing Li
  • Fonction : Auteur
Dunru Zhu
  • Fonction : Auteur
Ju‐zheng Wang
  • Fonction : Auteur
Sheng‐li Zhang
  • Fonction : Auteur
Xue‐ji Zhang
  • Fonction : Auteur
Guo‐fang Shu
  • Fonction : Auteur
Junji Li
  • Fonction : Auteur
Hai‐bo Zeng
  • Fonction : Auteur
Dan Shan

Résumé

High electrocatalytic activity with tunable luminescence is crucial for the development of electrochemiluminescence (ECL) luminophores. In this study, a porphyrin-based heterobimetallic 2D metal organic framework (MOF), [(ZnTCPP)Co2(MeIm)] (1), is successfully self-assembled from the zinc(II) tetrakis(4-carboxyphenyl)porphine (ZnTCPP) linker and cobalt(II) ions in the presence of 2-methylimidazole (MeIm) by a facile one-pot reaction in methanol at room temperature. On the basis of the experimental results and the theoretical calculations, the MOF 1 contains paddle-wheel [Co2(-CO2)4] secondary building units (SBUs) axially coordinated by a MeIm ligand, which is very beneficial to the electron transfer between the Co(II) ions and oxygen. Combining the photosensitizers ZnTCPP and the electroactive [Co2(-CO2)4] SBUs, the 2D MOF 1 possesses an excellent ECL performance, and can be used as a novel ECL probe for rapid nonamplified detection of the RdRp gene of SARS-CoV-2 with an extremely low limit of detection (≈30 aM).
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Dates et versions

hal-03797904 , version 1 (07-10-2022)

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Yi‐xuan Li, Jing Li, Dunru Zhu, Ju‐zheng Wang, Sheng‐li Zhang, et al.. 2D Zn‐Porphyrin‐Based Co(II)‐MOF with 2‐Methylimidazole Sitting Axially on the Paddle–Wheel Units: An Efficient Electrochemiluminescence Bioassay for SARS‐CoV‐2. Advanced Functional Materials, 2022, pp.2209743. ⟨10.1002/adfm.202209743⟩. ⟨hal-03797904⟩
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