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Article Dans Une Revue Biomolecules Année : 2022

Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death

Résumé

The localization of Bcl-2 family members at the mitochondrial outer membrane (MOM) is a crucial step in the implementation of apoptosis. We review evidence showing the role of the components of the mitochondrial import machineries (translocase of the outer membrane (TOM) and the sorting and assembly machinery (SAM)) in the mitochondrial localization of Bcl-2 family members and how these machineries regulate the function of pro- and anti-apoptotic proteins in resting cells and in cells committed into apoptosis
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Dates et versions

hal-03798301 , version 1 (05-10-2022)

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Lisenn Lalier, François M Vallette, Stéphen Manon. Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death. Biomolecules, 2022, 12 (2), pp.162. ⟨10.3390/biom12020162⟩. ⟨hal-03798301⟩
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