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Article Dans Une Revue Exploration of Targeted Anti-tumor Therapy Année : 2022

Yeast as a tool to decipher the molecular mechanisms underlying the functions of Bcl-2 family

Résumé

The budding yeast Saccharomyces cerevisiae, a favorite model in biology, does not contain any protein of the Bcl-2 family. From initial experiments with two-hybrid systems to the heterologous expression of human Bcl-2 family members, and the characterization of several forms of yeast programmed cell death, it has however always been a powerful tool to gain information on the mechanisms of apoptosis in general and on Bcl-2 family in particular. This is a short survey of 25 years of experiments that have provided, and at times initiated, insights into the molecular mechanisms underlying the function of Bcl-2 family members.
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Dates et versions

hal-03798308 , version 1 (05-10-2022)

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Stéphen Manon. Yeast as a tool to decipher the molecular mechanisms underlying the functions of Bcl-2 family. Exploration of Targeted Anti-tumor Therapy, 2022, pp.128 - 148. ⟨10.37349/etat.2022.00076⟩. ⟨hal-03798308⟩

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