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Article Dans Une Revue ACS Macro Letters Année : 2022

Degradable Polyampholytes from Radical Ring-Opening Copolymerization Enhance Cellular Cryopreservation

Résumé

Macromolecular cryoprotectants based on polyampholytes are showing promise as supplemental cryoprotectants alongside conventional DMSO-based freezing. Here we exploit radical ring-opening (ter)polymerization to access ester-containing cryoprotective polyampholytes, which were shown to be degradable. Using a challenging cell monolayer cryopreservation model, the degradable polyampholytes were found to enhance post-thaw recovery when supplemented into DMSO. This demonstrates that degradable macromolecular cryoprotectants can be developed for application in biotechnology and biomedicine.

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hal-03805533 , version 1 (07-10-2022)

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Théo Pesenti, Chen Zhu, Natalia Gonzalez-Martinez, Ruben M F Tomás, Matthew I Gibson, et al.. Degradable Polyampholytes from Radical Ring-Opening Copolymerization Enhance Cellular Cryopreservation. ACS Macro Letters, 2022, 11 (7), pp.889-894. ⟨10.1021/acsmacrolett.2c00298⟩. ⟨hal-03805533⟩
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