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Pré-Publication, Document De Travail Année : 2022

Telomere elongation in the gut extends zebrafish lifespan

Jean-Marie Guigonis
  • Fonction : Auteur
Thierry Pourchet
  • Fonction : Auteur
Da Kang
  • Fonction : Auteur
Jia-Xing Yue
  • Fonction : Auteur

Résumé

Telomere shortening is a hallmark of aging and is counteracted by telomerase. The gut is one of the earliest organs to exhibit short telomeres and tissue dysfunction during normal zebrafish aging. This is recapitulated in prematurely aged telomerase mutants ( tert-/- ). Here, we show that gut-specific telomerase activity in tert-/- zebrafish prevents premature aging. Induction of telomerase rescues gut senescence and low cell proliferation to wild-type levels, while restoring gut tissue integrity, inflammation, and age-dependent gut microbiota dysbiosis. Remarkably, averting gut dysfunction results in a systemic beneficial impact. Gut-specific telomerase activity rescues premature aging markers in remote organs, such as the reproductive (testes) and hematopoietic (kidney marrow) systems. Functionally, it also rescues age-dependent loss of male fertility and testes atrophy. Finally, we show that gut-specific telomerase activity increases the lifespan of telomerase mutants. Our work demonstrates that delaying telomere shortening in the gut is sufficient to systemically counteract aging in zebrafish.

Dates et versions

hal-03817707 , version 1 (17-10-2022)

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Citer

Mounir El Maï, Jean-Marie Guigonis, Thierry Pourchet, Da Kang, Jia-Xing Yue, et al.. Telomere elongation in the gut extends zebrafish lifespan. 2022. ⟨hal-03817707⟩
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