GABA-A rhythmic inhibition in the claustrum drives network oscillation
Résumé
The claustrum is phylogenetically highly preserved in amniotes, from reptiles and birds to mammals, including humans (Norimoto et al., 2020). It is a thin structure that lays deep between the insular cortex and the striatum. It contains a small proportion of interneurons of various types,
and a majority of far-projecting excitatory neurons. It is a high-level structure holding the most central position in the brain hierachy, being reciprocally connected to all cerebral cortical areas, to the amygdala, hippocampus, and thalamus. Its functional role is a recent focus of research in neurosciences as it remains largely unknown during both sleep and wakefulness. Due to its high connectivity it has been proposed to be a “seat of consciousness” and involved in multi-sensory binding (Crick & Koch, 2005), a hub for attention (Goll et al., 2015; Atlan et al., 2018; Fodoulian et al., 2020). Most importantly for the present work, the claustrum might orchestrate and integrate cortical activity by coordinating synchronized oscillations in cortical areas during sleep and quiet wakefulness (Narikiyo et al., 2020). The claustrum could act as a synchronizing relay between areas, activating their local GABAergic interneurons (Narikiyo et al., 2020). It could also act during sleep as a “conductor” (Crick & Koch, 2005), driving slow-wave sleep activity on its own rhythm.
Domaines
Neurosciences [q-bio.NC]
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