(CAAC)Copper Catalysis Enables Regioselective Three-Component Carboboration of Terminal Alkynes - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Pré-Publication, Document De Travail Année : 2022

(CAAC)Copper Catalysis Enables Regioselective Three-Component Carboboration of Terminal Alkynes

Résumé

Cyclic(alkyl)(amino)carbene (CAAC) ligands are found to perturb regioselectivity of the copper-catalyzed carboboration of terminal alkynes, favoring the less commonly observed internal alkenylboron regiosomer through an α-selective borylcupration step. A variety of carbon electrophiles participate in the reaction, including allyl alcohols derivatives and alkyl halides. The method provides a straightforward and selective route to versatile tri-substituted alkenylboron compounds that are otherwise challenging to access.
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Dates et versions

hal-03827967 , version 1 (26-10-2022)

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Citer

Yang Gao, Nana Kim, Sima Yazdani, Mingyu Liu, Aaron Kendrick, et al.. (CAAC)Copper Catalysis Enables Regioselective Three-Component Carboboration of Terminal Alkynes. 2022. ⟨hal-03827967⟩

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