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Article Dans Une Revue The Journal of Physiology Année : 2022

Hindbrain catecholaminergic inputs to the paraventricular thalamus scale feeding and metabolic efficiency in stress‐related contexts

Résumé

The regulation of food intake and energy balance relies on the dynamic integration of48 exteroceptive and interoceptive signals monitoring nutritional, metabolic, cognitive49 and emotional states. The paraventricular thalamus (PVT) is a central hub that, by50 integrating sensory, metabolic and emotional states, may contribute to the regulation51 of feeding and homeostatic/allostatic processes. However, the underlying PVT52 circuits remain still elusive. Here, we aimed at unraveling the role of53 catecholaminergic (CA) inputs to the PVT in scaling feeding and metabolic efficiency.54 First, using region-specific retrograde disruption of CA projections, we show that PVT55 CA inputs mainly arise from the hindbrain, notably the locus coeruleus (LC) and the56 nucleus tractus solitarius (NTS). Second, taking advantage of integrative calorimetric57 measurements of metabolic efficiency, we reveal that CA inputs to the PVT scale58 adaptive feeding and metabolic responses in environmental, behavioral,59 physiological and metabolic stress-like contexts. Third, we show that60 hindbrainTH→PVT inputs contribute in modulating the activity of PVT as well as61 lateral (LH) and dorsomedial (DMH) hypothalamic neurons.62 In conclusion, this study, by assessing the key role of CA inputs to the PVT in scaling63 homeostatic/allostatic regulations of feeding patterns, reveals the integrative and64 converging hindbrainTH→PVT paths that contribute to whole-body metabolic65 adaptations in stress-like contexts.
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Dates et versions

hal-03835810 , version 1 (15-11-2022)

Identifiants

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Clarisse Dumont, Guangping Li, Julien Castel, Serge Luquet, Giuseppe Gangarossa. Hindbrain catecholaminergic inputs to the paraventricular thalamus scale feeding and metabolic efficiency in stress‐related contexts. The Journal of Physiology, 2022, 600 (12), pp.2877-2895. ⟨10.1113/JP282996⟩. ⟨hal-03835810⟩
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