The Toll pathway mediates <i>Drosophila</i> resilience to <i>Aspergillus</i> mycotoxins through specific Bomanins - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue EMBO Reports Année : 2022

The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins

Franck Martin

Résumé

Host defense against infections encompasses both resistance, which targets microorganisms for neutralization or elimination, and resilience/disease tolerance, which allows the host to withstand/tolerate pathogens and repair damages. In Drosophila, the Toll signaling pathway is thought to mediate resistance against fungal infections by regulating the secretion of antimicrobial peptides, potentially including Bomanins. We find that Aspergillus fumigatus kills Drosophila Toll pathway mutants without invasion because its dissemination is blocked by melanization, suggesting a role for Toll in host defense distinct from resistance. We report that mutants affecting the Toll pathway or the 55C Bomanin locus are susceptible to the injection of two Aspergillus mycotoxins, restrictocin and verruculogen. The vulnerability of 55C deletion mutants to these mycotoxins is rescued by the overexpression of Bomanins specific to each challenge. Mechanistically, flies in which BomS6 is expressed in the nervous system exhibit an enhanced recovery from the tremors induced by injected verruculogen and display improved survival. Thus, innate immunity also protects the host against the action of microbial toxins through secreted peptides and thereby increases its resilience to infection.
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Dates et versions

hal-03843744 , version 1 (02-12-2022)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Rui Xu, Yanyan Lou, Antonin Tidu, Philippe Bulet, Thorsten Heinekamp, et al.. The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins. EMBO Reports, 2022, ⟨10.15252/embr.202256036⟩. ⟨hal-03843744⟩
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