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Pré-Publication, Document De Travail Année : 2022

Hindbrain catecholaminergic inputs to the paraventricular thalamus scale feeding and metabolic efficiency in stress-related contexts

Clarisse Dumont
  • Fonction : Auteur
Guangping Li
  • Fonction : Auteur
Julien Castel
Serge Luquet
Giuseppe Gangarossa

Résumé

Abstract The regulation of food intake and energy balance relies on the dynamic integration of exteroceptive and interoceptive signals monitoring nutritional, metabolic, cognitive and emotional states. The paraventricular thalamus (PVT) is a central hub that, by integrating sensory, metabolic and emotional states, may contribute to the regulation of feeding and homeostatic/allostatic processes. However, the underlying PVT circuits remain still elusive. Here, we aimed at unraveling the role of catecholaminergic (CA) inputs to the PVT in scaling feeding and metabolic efficiency. First, using region-specific retrograde disruption of CA projections, we show that PVT CA inputs mainly arise from the hindbrain, notably the locus coeruleus (LC) and the nucleus tractus solitarius (NTS). Second, taking advantage of integrative calorimetric measurements of metabolic efficiency, we reveal that CA inputs to the PVT scale adaptive feeding and metabolic responses in environmental, behavioral, physiological and metabolic stress-like contexts. Third, we show that hindbrain TH →PVT inputs contribute in modulating the activity of PVT as well as lateral (LH) and dorsomedial (DMH) hypothalamic neurons. In conclusion, this study, by assessing the key role of CA inputs to the PVT in scaling homeostatic/allostatic regulations of feeding patterns, reveals the integrative and converging hindbrain TH →PVT paths that contribute to whole-body metabolic adaptations in stress-like contexts. Key points The paraventricular thalamus (PVT) is known to receive projections from the hindbrain. Here, we confirm and further extend current knowledge on the existence of hindbrain TH →PVT catecholaminergic (CA) inputs, notably from the locus coeruleus (LC) and the nucleus tractus solitarius (NTS), with the NTS representing the main source. Disruption of hindbrain TH →PVT inputs contribute to the modulation of PVT-neurons activity. Hindbrain TH →PVT inputs scale feeding strategies in environmental, behavioral, physiological and metabolic stress-like contexts. Hindbrain TH →PVT inputs participate in regulating metabolic efficiency and nutrient partitioning in stress-like contexts. Hindbrain TH →PVT, directly and/or indirectly, contribute in modulating the downstream activity of lateral (LH) and dorsomedial (DMH) hypothalamic neurons.
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hal-03846811 , version 1 (10-11-2022)

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Clarisse Dumont, Guangping Li, Julien Castel, Serge Luquet, Giuseppe Gangarossa. Hindbrain catecholaminergic inputs to the paraventricular thalamus scale feeding and metabolic efficiency in stress-related contexts. 2022. ⟨hal-03846811⟩
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