%0 Journal Article %T Synthesis of novel 3’,3’‐cyclic dinucleotide analogues targeting STING protein %+ Institut de Chimie Organique et Analytique (ICOA) %+ Centre de biophysique moléculaire (CBM) %+ Immunologie et Neurogénétique Expérimentales et Moléculaires (INEM) %+ Czech Academy of Sciences [Prague] (CAS) %A Magand, Jérémy %A Roy, Vincent %A Meudal, Hervé %A Rose, Stéphanie %A Quesniaux, Valérie %A Chalupska, Dominika %A Agrofoglio, Luigi %Z Region Centre-Val de Loire (EURO-FéRI EX010381and EURO-FéRI EX010351) %Z FEDER TARGET-Ex EX016008)as well as by GAVO projet (MERSI-CNRS) %Z ICOA comes from CHemBio (FEDER-FSE 2014-2020-EX003677) %Z Techsab (FEDER-FSE 2014-2020-EX011313) %Z RTR Motivhealth (2019-00131403) %< avec comité de lecture %@ 2193-5807 %J Asian Journal of Organic Chemistry %I Wiley %V 2022 %P e202200597 %8 2022-11-06 %D 2022 %R 10.1002/ajoc.202200597 %Z Chemical Sciences %Z Life Sciences [q-bio]Journal articles %X The Stimulator of Interferon Genes (STING) plays an important role in innate immunity by inducing type I interferons in response to sensing viral or bacterial cytosolic DNA. Cyclic dinucleotides (CDNs) are known to activate STING. Here, we describe the synthesis and biological evaluation of two new 3’,3’-CDN, in which the internucleotide linkages were replaced, respectively, by a 1,2,3-triazole moiety (as more stable isosteres of phosphate linkers) and an unsaturated carbon chain (as flexibility can led to crucial binding affinity and specificity). Thus, CuAAC and macrocyclization by RCM are the two key steps %G English %2 https://hal.science/hal-03859427/document %2 https://hal.science/hal-03859427/file/Asian%20J%20Org%20Chem%20-%202022%20-%20Magand%20-%20Synthesis%20of%20novel%203%203%20%E2%80%90cyclic%20dinucleotide%20analogues%20targeting%20STING%20protein.pdf %L hal-03859427 %U https://hal.science/hal-03859427 %~ CEA %~ CNRS %~ UNIV-ORLEANS %~ ICOA %~ CBM %~ INC-CNRS %~ ANR %~ TEST2-HALCNRS %~ LABOS-SYNORG %~ PUBLIS-SYNORG