Macrophages Induce Long-Term Trapping of γδ T Cells with Innate-like Properties within Secondary Lymphoid Organs in the Steady State - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Journal of Immunology Année : 2017

Macrophages Induce Long-Term Trapping of γδ T Cells with Innate-like Properties within Secondary Lymphoid Organs in the Steady State

Alexandra Audemard-Verger
  • Fonction : Auteur
  • PersonId : 1048227
Matthieu Rivière
Aurélie Durand
  • Fonction : Auteur
  • PersonId : 970485
Elisa Peranzoni
Nelly Bonilla
  • Fonction : Auteur
Thomas Guilbert
Cédric Auffray
  • Fonction : Auteur
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Bruno Lucas
Bruno Martin
  • Fonction : Auteur correspondant

Résumé

So far, peripheral T cells have mostly been described to circulate between blood, secondary lymphoid organs (SLOs), and lymph in the steady state. This nomadic existence would allow them to accomplish their surveying task for both foreign Ags and survival signals. Although it is now well established that γδ T cells can be rapidly recruited to inflammatory sites or in certain tumor microenvironments, the trafficking properties of peripheral γδ T cells have been poorly studied in the steady state. In the present study, we highlight the existence of resident γδ T cells in the SLOs of specific pathogen-free mice. Indeed, using several experimental approaches such as the injection of integrin-neutralizing Abs that inhibit the entry of circulating lymphocytes into lymph nodes and long-term parabiosis experiments, we have found that, contrary to Ly-6C−/+CD44lo and Ly-6C+CD44hi γδ T cells, a significant proportion of Ly-6C−CD44hi γδ T cells are trapped for long periods of time within lymph nodes and the spleen in the steady state. Specific in vivo cell depletion strategies have allowed us to demonstrate that macrophages are the main actors involved in this long-term retention of Ly-6C−CD44hi γδ T cells in SLOs
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hal-03863963 , version 1 (06-03-2023)

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Alexandra Audemard-Verger, Matthieu Rivière, Aurélie Durand, Elisa Peranzoni, Vincent Guichard, et al.. Macrophages Induce Long-Term Trapping of γδ T Cells with Innate-like Properties within Secondary Lymphoid Organs in the Steady State. Journal of Immunology, 2017, 199 (6), pp.1998-2007. ⟨10.4049/jimmunol.1700430⟩. ⟨hal-03863963⟩
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