Nigratine as first-in-class dual inhibitor of necroptosis and ferroptosis regulated cell death - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Pré-Publication, Document De Travail (Preprint/Prepublication) Année : 2022

Nigratine as first-in-class dual inhibitor of necroptosis and ferroptosis regulated cell death

Résumé

Nigratine (also known as 6E11), a natural flavanone derivative, was characterized as highly specific non-ATP competitive inhibitor of RIPK1 kinase, one of the key component of necroptotic cell death signaling. We show here that nigratine inhibited both necroptosis (induced by Tumor Necrosis Factor-α) and ferroptosis (induced by glutamate, erastin or RSL3 small chemical compounds) with EC50 in the µM range. Altogether, the data obtained showed that nigratine is the first-in-class dual inhibitor of necroptosis and ferroptosis cell death routes and opened new therapeutic avenues for treating complex necrosis-related diseases.
Fichier principal
Vignette du fichier
86-Delehouzé_et_al_PrePrint_BioRx.pdf (848.01 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03867390 , version 1 (23-11-2022)

Identifiants

Citer

Claire Delehouzé, Arnaud Comte, Marcelle Hauteville, Peter G Goekjian, Marie-Thérèse Dimanche-Boitrel, et al.. Nigratine as first-in-class dual inhibitor of necroptosis and ferroptosis regulated cell death. 2022. ⟨hal-03867390⟩
81 Consultations
34 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More