Serum Albumin Antifouling Effects of Hydroxypropylcellulose and Pluronic F127 Adsorbed on Isobutyramidegrafted Stellate Silica Nanoparticles - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue European Journal of Inorganic Chemistry Année : 2021

Serum Albumin Antifouling Effects of Hydroxypropylcellulose and Pluronic F127 Adsorbed on Isobutyramidegrafted Stellate Silica Nanoparticles

Résumé

Limiting the serum protein fouling is a major challenge in the design of nanoparticles (NPs) for nanomedicine applications. Suitable chemical surface modification strategies allow to limit the interactions with adsorbing proteins. In this communication, we address the potential of isobutyramide (IBAM) groups grafted on stellate silica nanoparticles (STMS) for the immobilization of two biocompatible polymers renown for biomedical and low fouling applications: Hydroxypropylcellulose (HPC) and Pluronic F127 (PF127). We report that both polymers can be loaded on STMS@IBAM NPs surface with a maximum loading content close to 10 wt %. Regarding their antifouling properties, we report that the coatings of such HPC or PF127 polymers allow to reduce significantly the human serum albumin (HSA) adsorption in average by 70 % as compared to the surface of the free polymer STMS@IBAM. These results highlight the antifouling potential of these polymer pretreatments on IBAM-modified STMS NPs surface.
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Dates et versions

hal-03872451 , version 1 (25-11-2022)

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Joëlle Bizeau, Alexandre Adam, Sylvie Bégin-Colin, Damien Mertz. Serum Albumin Antifouling Effects of Hydroxypropylcellulose and Pluronic F127 Adsorbed on Isobutyramidegrafted Stellate Silica Nanoparticles. European Journal of Inorganic Chemistry, 2021, 2021 (46), pp.4799-4805. ⟨10.1002/ejic.202100678⟩. ⟨hal-03872451⟩
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