%0 Journal Article %T Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics %+ Department of Ophthalmology, Icahn School of Medicine at Mt. Sinai, New York, NY 10029, USA %+ Icahn School of Medicine at Mount Sinai [New York] (MSSM) %+ Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA %+ Department of Ophthalmology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA %+ Rochester Institute of Technology %+ Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145) %+ Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States %+ Department of Surgical and Clinical, Diagnostic and Pediatric Sciences, Section of Ophthalmology, Universita degli Studi di Pavia, Pavia, Lombardia, Italy IRCCS Fondazione Policlinico San Matteo, Pavia, Italy %+ Fondazione GB Bietti per l'Oftalmologia, IRCCS, Via Livenza 3, 00198, Roma %+ University of Missouri [Columbia] (Mizzou) %A Verticchio Vercellin, Alice %A Harris, Alon %A Belamkar, Aditya %A Zukerman, Ryan %A Carichino, Lucia %A Szopos, Marcela %A Siesky, Brent %A Quaranta, Luciano %A Bruttini, Carlo %A Oddone, Francesco %A Riva, Ivano %A Guidoboni, Giovanna %< avec comité de lecture %@ 2304-6732 %J Photonics %I MDPI %V 9 %N 3 %P 158 %8 2022-03 %D 2022 %R 10.3390/photonics9030158 %Z Mathematics [math] %Z Life Sciences [q-bio] %Z Computer Science [cs]Journal articles %X Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (pe-) analysis of the Mont Blanc study (MBS), estimating the effects of altitude on IOP, blood pressure (BP), and retinal hemodynamics. In the MBS, IOP and BP were measured in 33 healthy volunteers at 77 and 3466 m above sea level. Pe-retinal hemodynamics analysis predicted a statistically significant increase (p < 0.001) in the model predicted blood flow and pressure within the retinal vasculature following increases in systemic BP with altitude measured in the MBS. Decreased IOP with altitude led to a non-monotonic behavior of the model predicted retinal vascular resistances, with significant decreases in the resistance of the central retinal artery (p < 0.001) and retinal venules (p = 0.003) and a non-significant increase in the resistance in the central retinal vein (p = 0.253). Pe-aqueous humor analysis showed that a decrease in osmotic pressure difference (OPD) may underlie the difference in IOP measured at different altitudes in the MBS. Our analysis suggests that venules bear the significant portion of the IOP pressure load within the ocular vasculature, and that OPD plays an important role in regulating IOP with changes in altitude. %G English %L hal-03890278 %U https://cnrs.hal.science/hal-03890278 %~ CNRS %~ INSMI %~ MAP5 %~ UNIV-PARIS %~ UNIVERSITE-PARIS %~ UP-SCIENCES