Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Brain, Behavior, and Immunity Année : 2023

Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort

Aiste Lengvenyte (1, 2, 3, 4) , Robertas Strumila (1, 2, 3) , Raoul Belzeaux (5, 4, 6, 2) , Bruno Aouizerate (7, 8, 4) , Caroline Dubertret (4, 9, 10) , Emmanuel Haffen (4, 11, 12) , Pierre-Michel Llorca (4, 13, 14) , Paul Roux (4, 15, 16) , Mircea Polosan (17, 18, 4) , Raymund Schwan (19, 4, 20) , Michel Walter (4, 21) , Thierry d'Amato (22, 4) , Dominique Januel (23, 4) , Marion Leboyer (24, 25, 4, 26) , Frank Bellivier (27, 28, 4) , Bruno Etain (4, 27, 28) , Alvydas Navickas (3) , Émilie Olié (1, 2, 4) , Philippe Courtet (1, 2, 4)
1 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
2 IGF - Institut de Génomique Fonctionnelle
3 Vilnius University [Vilnius]
4 Fondation FondaMental [Créteil]
5 INT - Institut de Neurosciences de la Timone
6 APHM - Assistance Publique - Hôpitaux de Marseille
7 NutriNeuro - Nutrition et Neurobiologie intégrée
8 Centre hospitalier Charles Perrens [Bordeaux]
9 IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris
10 Hôpital Louis Mourier - AP-HP [Colombes]
11 Inserm CIC 1431 - Centre d'Investigation Clinique de Besançon
12 UBFC - Université Bourgogne Franche-Comté [COMUE]
13 CHU Clermont-Ferrand
14 UCA - Université Clermont Auvergne
15 CHV - Centre Hospitalier de Versailles André Mignot
16 CESP - Centre de recherche en épidémiologie et santé des populations
17 GIN - [GIN] Grenoble Institut des Neurosciences
18 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
19 IADI - Imagerie Adaptative Diagnostique et Interventionnelle
20 CPN - Centre Psychothérapique de Nancy [Laxou]
21 CHU - BREST - Hopital de Bohars - CHRU Brest
22 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
23 URCVE - Unité de Recherche Clinique de l'Hôpital de Ville-Evrard [Neuilly-sur-​Marne]
24 IMRB - Institut Mondor de Recherche Biomédicale
25 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
26 CHU Henri Mondor [Créteil]
27 Hôpital Lariboisière-Fernand-Widal [APHP]
28 OPTeN (UMR_S 1144 / U1144) - Optimisation thérapeutique en Neuropsychopharmacologie

Résumé

Evidences suggest that inflammation is increased in a subgroup of patients with depression. Moreover, increased peripheral inflammatory markers (cells and proteins) are associated with some, but not all depressive symptoms. On the other hand, similar studies on bipolar disorders mainly focused on blood cytokines. Here, we analysed data from a large (N = 3440), well-characterized cohort of individuals with bipolar disorder using Kendall partial rank correlation, multivariate linear regression, and network analyses to determine whether peripheral blood cell counts are associated with depression severity, its symptoms, and dimensions. Based on the self-reported 16-Item Quick Inventory of Depressive Symptomatology questionnaire scores, we preselected symptom dimensions based on literature and data-driven principal component analysis. We found that the counts of all blood cell types were only marginally associated with depression severity. Conversely, white blood cell count was significantly associated with the sickness dimension and its four components (anhedonia, slowing down, fatigue, and appetite loss). Platelet count was associated with the insomnia/restlessness dimension and its components (initial, middle, late insomnia and restlessness). Principal component analyses corroborated these results. Platelet count was also associated with suicidal ideation. In analyses stratified by sex, the white blood cell count-sickness dimension association remained significant only in men, and the platelet count-insomnia/restlessness dimension association only in women. Without implying causation, these results suggest that peripheral blood cell counts might be associated with different depressive symptoms in individuals with bipolar disorder, and that white blood cells might be implicated in sickness symptoms and platelets in insomnia/agitation and suicidal ideation.

Dates et versions

hal-03900847 , version 1 (15-12-2022)

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Aiste Lengvenyte, Robertas Strumila, Raoul Belzeaux, Bruno Aouizerate, Caroline Dubertret, et al.. Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort. Brain, Behavior, and Immunity, 2023, 108, pp.176-187. ⟨10.1016/j.bbi.2022.12.002⟩. ⟨hal-03900847⟩
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