Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 1995

Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice.

Résumé

The Hoxd-11 gene was disrupted by homologous recombination in embryonic stem cells. We found that Hoxd-11-/- mutant mice are viable and display homeotic transformations of their sacral vertebrae, while their forelimbs present abnormalities of some metacarpals and of the first row of carpal bones. These results are discussed in the light of current models of tetrapod axial skeleton and limb patterning.

Dates et versions

hal-03926095 , version 1 (06-01-2023)

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Bertrand Favier, Marianne Le Meur, Pierre Chambon, Pascal Dollé. Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice.. Proceedings of the National Academy of Sciences of the United States of America, 1995, 92 (1), pp.310-314. ⟨10.1073/pnas.92.1.310⟩. ⟨hal-03926095⟩
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