Photo‐Oxidizing Ruthenium(II) Complexes with Enhanced Visible‐Light Absorption and G‐quadruplex DNA Binding Abilities - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Chemistry - A European Journal Année : 2022

Photo‐Oxidizing Ruthenium(II) Complexes with Enhanced Visible‐Light Absorption and G‐quadruplex DNA Binding Abilities

Résumé

Photosensitizers that gather high photo-oxidizing power and strong visible-light absorption are of great interest in the development of new photo-chemotherapeutics. Indeed, such compounds constitute attractive candidates for the design of type I photosensitizers that are not dependent on the presence of oxygen. In this paper, we report on the synthesis and studies of new ruthenium(II) complexes that display strong visible-light absorption and can oxidize guanine residues under visible-light irradiation, as evidenced by nanosecond transient absorption spectroscopy. The reported compounds also tightly bind to G-quadruplex DNA structures from the human telomeric sequence (TTAGGG repeat). The kinetic and thermodynamic parameters of the interaction of these Ru(II) complexes with G-quadruplex and duplex DNA were studied thanks to luminescence titrations and bio-layer interferometry measurements, which revealed higher affinities towards the non-canonical G-quadruplex architecture. Docking experiments and non-covalent ionic analysis allowed us to gain information on the mode and the strength of the interaction of the compounds towards G-quadruplex and duplex DNA. The different studies emphasize the substantial influence of the position and the number of non-chelating nitrogen atoms on the interaction with both types of DNA secondary structures.
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Dates et versions

hal-03933090 , version 1 (10-01-2023)

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Martin Gillard, Guillaume Piraux, Martin Daenen, Michaël Abraham, Ludovic Troian-Gautier, et al.. Photo‐Oxidizing Ruthenium(II) Complexes with Enhanced Visible‐Light Absorption and G‐quadruplex DNA Binding Abilities. Chemistry - A European Journal, 2022, 28 (66), pp.e202202251. ⟨10.1002/chem.202202251⟩. ⟨hal-03933090⟩
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