Luminescent ruthenium(II) complexes used for the detection of 8oxoguanine in the human telomeric sequence - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Bioconjugate Chemistry Année : 2023

Luminescent ruthenium(II) complexes used for the detection of 8oxoguanine in the human telomeric sequence

Résumé

Detecting cancer at the early stage of the disease is crucial to keep the best chance for successful treatment. The recent development of genomic screening, a methodology that is addressed to asymptomatic patients presumably at risk of carcinogenesis, has stimulated the quest for new tools able to signal the level of risk. Carcinogenesis has been associated to chronic oxidative stress exceeding the antioxidant defenses and leading to critical genome alteration levels. The telomeric regions are presumably the most exposed to oxidative stress due to their high concentration of guanine (i.e. the easiest oxidizable nucleic base). Accumulation of 8-oxoguanine in telomeres, thus oxidative lesions, was reportedly associated with telomeric crisis and carcinogenesis. In this study, we report on the capacity of Ru(II) polyazaaromatic complexes to photoprobe 8-oxoguanine into the human telomeric sequence with the view of developing new tools for cancer risk screening.
Fichier principal
Vignette du fichier
soumission.pdf (588.5 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03953381 , version 1 (24-01-2023)

Identifiants

Citer

Martin Gillard, Hugues Bonnet, Rémy Lartia, Hiba Yacoub, Jérôme Dejeu, et al.. Luminescent ruthenium(II) complexes used for the detection of 8oxoguanine in the human telomeric sequence. Bioconjugate Chemistry, 2023, 34, pp.414-421. ⟨10.1021/acs.bioconjchem.2c00578⟩. ⟨hal-03953381⟩
17 Consultations
40 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More