What Is the Benefit of Ramped Pulse Shapes for Activating Auditory Cortex Neurons? An Electrophysiological Study in an Animal Model of Cochlear Implant - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Brain Sciences Année : 2023

What Is the Benefit of Ramped Pulse Shapes for Activating Auditory Cortex Neurons? An Electrophysiological Study in an Animal Model of Cochlear Implant

Résumé

In all commercial cochlear implant (CI) devices, the activation of auditory nerve fibers is performed with rectangular pulses that have two phases of opposite polarity. Recently, several papers proposed that ramped pulse shapes could be an alternative shape for efficiently activating auditory nerve fibers. Here, we investigate whether ramped pulse shapes can activate auditory cortex (ACx) neurons in a more efficient way than the classical rectangular pulses. Guinea pigs were implanted with CI devices and responses of ACx neurons were tested with rectangular pulses and with four ramped pulse shapes, with a first-phase being either cathodic or anodic. The thresholds, i.e., the charge level necessary for obtaining significant cortical responses, were almost systematically lower with ramped pulses than with rectangular pulses. The maximal firing rate (FR) elicited by the ramped pulses was higher than with rectangular pulses. As the maximal FR occurred with lower charge levels, the dynamic range (between threshold and the maximal FR) was not modified. These effects were obtained with cathodic and anodic ramped pulses. By reducing the charge levels required to activate ACx neurons, the ramped pulse shapes should reduce charge consumption and should contribute to more battery-efficient CI devices in the future.
Fichier principal
Vignette du fichier
Partouche et al 2023.pdf (1.5 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03971082 , version 1 (03-02-2023)

Identifiants

Citer

Elie Partouche, Victor Adenis, Pierre Stahl, Chloé Huetz, Jean-Marc Edeline. What Is the Benefit of Ramped Pulse Shapes for Activating Auditory Cortex Neurons? An Electrophysiological Study in an Animal Model of Cochlear Implant. Brain Sciences, 2023, 13 (250), pp.1-17. ⟨10.3390/brainsci13020250⟩. ⟨hal-03971082⟩
16 Consultations
24 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More