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Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2023

Dendrimer nanosystems for adaptive tumor-assisted drug delivery via extracellular vesicle hijacking

Xing-Jie Liang

Résumé

Drug delivery systems (DDSs) that can overcome tumor heterogeneity and achieve deep tumor penetration are challenging to develop yet in high demand for cancer treatment. We report here a DDS based on self-assembling dendrimer nanomicelles for effective and deep tumor penetration via in situ tumor-secreted extracellular vesicles (EVs), an endogenous transport system that evolves with tumor microenvironment. Upon arrival at a tumor, these dendrimer nanomicelles had their payload repackaged by the cells into EVs, which were further transported and internalized by other cells for delivery “in relay.” Using pancreatic and colorectal cancer-derived 2D, 3D, and xenograft models, we demonstrated that the in situ-generated EVs mediated intercellular delivery, propagating cargo from cell to cell and deep within the tumor. Our study provides a new perspective on exploiting the intrinsic features of tumors alongside dendrimer supramolecular chemistry to develop smart and effective DDSs to overcome tumor heterogeneity and their evolutive nature thereby improving cancer therapy
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Dates et versions

hal-03977439 , version 1 (07-02-2023)

Identifiants

Citer

Yifan Jiang, Zhenbin Lyu, Brigino Ralahy, Juan Liu, Tom Roussel, et al.. Dendrimer nanosystems for adaptive tumor-assisted drug delivery via extracellular vesicle hijacking. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120, ⟨10.1073/pnas.2215308120⟩. ⟨hal-03977439⟩
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