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Article Dans Une Revue Biology of the Cell Année : 2023

The microtubule lattice ‐ a brief historical perspective

Résumé

At first glance, the structure of a microtubule is simple. Globular α- and β-tubulin subunits form constitutive heterodimers that align head-to-tail in protofilaments. In the most common configuration, 13 protofilaments associate laterally with a slight longitudinal stagger that results in a left-handed 3-start helix featuring lateral associations between tubulin subunits. This seemingly straightforward description is actually based on almost half a century of research aimed at understanding how tubulin dimers interact within the microtubule lattice. But while we start to have a good overview of their architecture in vitro, our knowledge of microtubule-lattice organization in vivo is nowhere near to being complete.
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Dates et versions

hal-03984704 , version 1 (12-06-2023)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Denis Chrétien, Charlotte Guyomar. The microtubule lattice ‐ a brief historical perspective. Biology of the Cell, 2023, 115 (5), pp.e202300004. ⟨10.1111/boc.202300004⟩. ⟨hal-03984704⟩
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