Molecular chaperones, proteases, and unfolded protein responses
Résumé
Cells must ensure protein homeostasis to live and sustain growth. Important players for achieving this are molecular chaperones and proteases. In this chapter we describe our current knowledge of small heat shock proteins, chaperonins and cochaperonins, HSP70 and its cochaperones, HSP90 and its cochaperones, HSP100/ClpB, as well as of the protease systems ClpP, FtsH and Deg in Chlamydomonas reinhardtii. Moreover, we elaborate on how imbalances of protein homeostasis in different compartments of a Chlamydomonas cell are sensed to trigger compartment-specific unfolded protein responses.
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