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Article Dans Une Revue Journal of Immunology Année : 2017

Immune Modifications in Fetal Membranes Overlying the Cervix Precede Parturition in Humans

Louis Marcellin
Thomas Schmitz
  • Fonction : Auteur
Meriem Messaoudene
Driss Chader
Sébastien Jacques
  • Fonction : Auteur
Jérémy Delaire
  • Fonction : Auteur
Jean Gogusev
  • Fonction : Auteur
Alain Schmitt
  • Fonction : Auteur
Corinne Lesaffre
  • Fonction : Auteur
Michelle Breuiller-Fouché
  • Fonction : Auteur
Anne Caignard
Daniel Vaiman
  • Fonction : Auteur
François Goffinet
  • Fonction : Auteur
Dominique Cabrol
Guy Gorochov
  • Fonction : Auteur
Céline Méhats

Résumé

Abstract In humans, parturition is currently viewed as an intrauterine outbreak of inflammation, accompanied by a massive release of proinflammatory cytokines at the maternal–fetal interface that comprises the maternal decidua, placenta, and fetal membranes. At term, fetal membranes overlying the cervix, the future site of rupture, show altered morphology and are termed the zone of altered morphology (ZAM). These alterations occur in normal fetal membranes during late pregnancy, in preparation for labor. In this study, transcriptome, flow cytometry, electron microscopy, and immunohistochemistry analyses collectively highlight a local shift in gene expression and lymphocyte activation in the ZAM. Just before labor, we show that highly polymorphic HLA-A, -B, and -C determinants of fetal origin are selectively exposed in the ZAM to the maternal immune system. A graft rejection-like program occurs in the ZAM, which involves 1) the activation of cytotoxic decidual NK cells, and 2) the decline of decidual immunotolerant M2-like macrophages. Comparison with a prior cohort of fetal membranes shows that acute inflammation only takes place after these first steps of immune modifications. Our results therefore strongly argue in favor of local immune remodeling at the onset of parturition.

Domaines

Immunologie
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Dates et versions

hal-04002531 , version 1 (23-02-2023)

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Citer

Louis Marcellin, Thomas Schmitz, Meriem Messaoudene, Driss Chader, Christophe Parizot, et al.. Immune Modifications in Fetal Membranes Overlying the Cervix Precede Parturition in Humans. Journal of Immunology, 2017, 198 (3), pp.1345-1356. ⟨10.4049/jimmunol.1601482⟩. ⟨hal-04002531⟩
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