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Pré-Publication, Document De Travail Année : 2023

A neural field model for ignition and propagation of cortical spreading depression

Un modèle de champ neuronal pour l'allumage et la propagation de la dépression corticale propagée

Résumé

We propose a new neural field model for migraine-related cortical spreading depression (CSD). The model follows the Wilson-Cowan-Amari formalism. It is based on an excitatory-inhibitory neuron population pair which is coupled to a potassium concentration variable. This model is spatially extended to a cortical layer. Therefore, it can model both the ignition and propagation of CSD. It controls the propagation speed via connection weights and contribution weight of each population activity to the potassium accumulation in the extracellular matrix. The simulation results regarding the propagation speed are in coherence with the experiment results provided in Chever et al. (2021).
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Dates et versions

hal-04008117 , version 1 (28-02-2023)

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Paternité

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  • HAL Id : hal-04008117 , version 1

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E Baspinar, D Avitabile, M Desroches, M Mantegazza. A neural field model for ignition and propagation of cortical spreading depression. 2023. ⟨hal-04008117⟩
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