Brain Metabolic Alterations in Seropositive Autoimmune Encephalitis: An (18)F-FDG PET Study - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Biomedicines Année : 2023

Brain Metabolic Alterations in Seropositive Autoimmune Encephalitis: An (18)F-FDG PET Study

Sébastien Bergeret
Cristina Birzu
  • Fonction : Auteur
  • PersonId : 1091422
Alain Giron
  • Fonction : Auteur
  • PersonId : 1137837
Sophie Demeret
  • Fonction : Auteur
  • PersonId : 1094895
Clémence Marois
  • Fonction : Auteur
Louis Cousyn
  • Fonction : Auteur
  • PersonId : 1079306
Laura Rozenblum
  • Fonction : Auteur
  • PersonId : 1207881
Agusti Alentorn
Vincent Navarro
  • Fonction : Auteur
  • PersonId : 1062634
Dimitri Psimaras
  • Fonction : Auteur
  • PersonId : 1076787
Aurélie Kas
  • Fonction : Auteur
  • PersonId : 1140273

Résumé

INTRODUCTION: Autoimmune encephalitis (AE) diagnosis and follow-up remain challenging. Brain (18)F-fluoro-deoxy-glucose positron emission tomography (FDG PET) has shown promising results in AE. Our aim was to investigate FDG PET alterations in AE, according to antibody subtype. METHODS: We retrospectively included patients with available FDG PET and seropositive AE diagnosed in our center between 2015 and 2020. Brain PET Z-score maps (relative to age matched controls) were analyzed, considering metabolic changes significant if |Z-score| ≥ 2. RESULTS: Forty-six patients were included (49.4 yrs [18; 81]): 13 with GAD autoantibodies, 11 with anti-LGI1, 9 with NMDAR, 5 with CASPR2, and 8 with other antibodies. Brain PET was abnormal in 98% of patients versus 53% for MRI. The most frequent abnormalities were medial temporal lobe (MTL) and/or striatum hypermetabolism (52% and 43% respectively), cortical hypometabolism (78%), and cerebellum abnormalities (70%). LGI1 AE tended to have more frequent MTL hypermetabolism. NMDAR AE was prone to widespread cortical hypometabolism. Fewer abnormalities were observed in GAD AE. Striatum hypermetabolism was more frequent in patients treated for less than 1 month (p = 0.014), suggesting a relation to disease activity. CONCLUSION: FDG PET could serve as an imaging biomarker for early diagnosis and follow-up in AE.
Fichier principal
Vignette du fichier
biomedicines-11-00506-v2.pdf (1.06 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04013428 , version 1 (03-03-2023)

Licence

Paternité

Identifiants

Citer

Sébastien Bergeret, Cristina Birzu, Pierre Meneret, Alain Giron, Sophie Demeret, et al.. Brain Metabolic Alterations in Seropositive Autoimmune Encephalitis: An (18)F-FDG PET Study. Biomedicines, 2023, 11 (2), pp.506. ⟨10.3390/biomedicines11020506⟩. ⟨hal-04013428⟩
49 Consultations
14 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More