Investigation of chemical composition and biological activities of $Ajuga\ pyramidalis$—isolation of iridoids and phenylethanoid glycosides - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Metabolites Année : 2023

Investigation of chemical composition and biological activities of $Ajuga\ pyramidalis$—isolation of iridoids and phenylethanoid glycosides

Résumé

Despite several studies on the Ajuga L. genus, the chemical composition of $Ajuga\ pyramidalis$, an alpine endemic species, is still largely unknown. The purpose of this study was to therefore deeper describe it, particularly from the phytochemistry and bioactivity perspectives. In that respect, $A.\ pyramidalis$ was investigated and 95% of the extracted mass of the plant was characterized by chromatography and mass spectrometry. Apart from the already determined chemical compounds, namely, harpagide and 8-O-acetylharpagide, two iridoids, and neoajugapyrin A, a neo-clerodane diterpene, and three polyphenols (echinacoside, verbascoside and teupoloside) were identified for the first time in $A.\ pyramidalis$. Incidentally, the first RX structure of a harpagoside derivative is also described in this paper. The extracts and isolated compounds were then evaluated for various biochemical or biological activities; notably a targeted action on the renewal of the epidermis was highlighted with potential applications in the cosmetic field for anti-aging.
Fichier principal
Vignette du fichier
Gori-metabolites-2023.pdf (2.85 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04014499 , version 1 (04-03-2023)

Licence

Paternité

Identifiants

Citer

Anthonin Gori, Benjamin Boucherle, Aurélien Rey, Maxime Rome, Caroline Barette, et al.. Investigation of chemical composition and biological activities of $Ajuga\ pyramidalis$—isolation of iridoids and phenylethanoid glycosides. Metabolites, 2023, 13, pp.128. ⟨10.3390/metabo13010128⟩. ⟨hal-04014499⟩
30 Consultations
22 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More