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Article Dans Une Revue Journal of Clinical Endocrinology and Metabolism Année : 1998

DAX-1 Expression in Human Adrenocortical Neoplasms: Implications for Steroidogenesis

Résumé

The DAX-1 gene encodes an orphan nuclear hormone receptor essential for normal fetal development of the adrenal cortex. Recently, DAX-1 has been shown to act as a transcriptional repressor of steroidogenic acute regulatory protein gene expression (StAR), suppressing steroidogenesis. We, therefore, investigated the expression of DAX-1 in a variety of adrenocortical tumors and compared the results with StAR mRNA expression. We found low or absent DAX-1 expression in aldosterone-producing adenomas (n=11: 35±11%; normal adrenals: 100±17%) and in aldosterone-producing adrenocortical carcinomas (n=2: 24 and 36%). Cortisol-producing adenomas showed intermediate DAX-1 expression (n=8; 92±16), as did 3 non-aldosterone-producing carcinomas (72, 132 and 132%). High DAX-1 expression was present in nonfunctional adenomas (n=3; 160±17%). In contrast to DAX-1, StAR mRNA expression did not show significant variations between groups. We did not detect the expected negative correlation between DAX-1 and StAR mRNA in adrenocortical tumors. These data suggest that high DAX-1 expression in adrenocortical tumors is associated with a non-functional phenotype whereas low DAX-1 expression favors mineralo-corticoid secretion. These effects on steroidogenesis are mediated by mechanisms other than repression of StAR gene expression. Our results indicate that DAX-1 may be one of the factors influencing the steroid biosynthesis of adrenocortical neoplasms.

Dates et versions

hal-04016890 , version 1 (06-03-2023)

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Citer

M. Reincke, F. Beuschlein, E. Lalli, W. Arlt, S. Vay, et al.. DAX-1 Expression in Human Adrenocortical Neoplasms: Implications for Steroidogenesis. Journal of Clinical Endocrinology and Metabolism, 1998, 83 (7), pp.2597-2600. ⟨10.1210/jcem.83.7.5095⟩. ⟨hal-04016890⟩
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