Impact of response shift effects in the assessment of selfreported depression during treatment: insights from a rTMS versus Venlafaxine randomized controlled trial - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Journal of Psychiatric Research Année : 2023

Impact of response shift effects in the assessment of selfreported depression during treatment: insights from a rTMS versus Venlafaxine randomized controlled trial

Résumé

Patient-Reported Outcomes are essential to properly assess treatment effectiveness in randomized clinical trial (RCT) for Major Depressive Disorder (MDD). MDD self-assessment may vary over time depending on change in the meaning of patients' self-evaluation of depression, i.e. Response Shift (RS). Our aim was to investigate RS and its impact on different depression domains in a clinical trial comparing rTMS versus Venlafaxine. Methods: The occurrence and type of RS was determined using Structural Equation Modeling applied to change over time in 3 domains (Sad Mood, Performance Impairment, Negative Self-Reference) of the short-form Beck Depression Inventory (BDI-13) in a secondary analysis of a RCT on 170 patients with MDD treated by rTMS, venlafaxine or both. Results: RS was evidenced in the venlafaxine group in the Negative Self-Reference and Sad Mood domains. Conclusion: RS effects differed between treatment arms in self-reported depression domains in patients with MDD. Ignoring RS would have led to a slight underestimation of depression improvement, depending on treatment group. Further investigations of RS and advancing new methods are needed to better inform decision making based on Patient-Reported Outcomes.
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Dates et versions

hal-04030560 , version 1 (15-03-2023)

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Samuel Bulteau, Myriam Blanchin, Morgane Pere, Emmanuel Poulet, Jérôme Brunelin, et al.. Impact of response shift effects in the assessment of selfreported depression during treatment: insights from a rTMS versus Venlafaxine randomized controlled trial. Journal of Psychiatric Research, 2023, 160, pp.117-125. ⟨10.1016/j.jpsychires.2023.02.016⟩. ⟨hal-04030560⟩
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