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Article Dans Une Revue Science Année : 1999

Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3

Résumé

During the immediate-early response of mammalian cells to mitogens, histone H3 is rapidly and transiently phosphorylated by one or more unidentified kinases. Rsk-2, a member of the pp90rsk family of kinases implicated in growth control, was required for epidermal growth factor (EGF)-stimulated phosphorylation of H3. RSK-2 mutations in humans are linked to Coffin-Lowry syndrome (CLS). Fibroblasts derived from a CLS patient failed to exhibit EGF-stimulated phosphorylation of H3, although H3 was phosphorylated during mitosis. Introduction of the wild-type RSK-2 gene restored EGF-stimulated phosphorylation of H3 in CLS cells. In addition, disruption of the RSK-2 gene by homologous recombination in murine embryonic stem cells abolished EGF-stimulated phosphorylation of H3. H3 appears to be a direct or indirect target of Rsk-2, suggesting that chromatin remodeling might contribute to mitogen-activated protein kinase-regulated gene expression.
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Dates et versions

hal-04035520 , version 1 (17-03-2023)

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Paolo Sassone-Corsi, Craig A. Mizzen, Peter Cheung, Claudia Crosio, Lucia Monaco, et al.. Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science, 1999, 285 (5429), pp.886-891. ⟨10.1126/science.285.5429.886⟩. ⟨hal-04035520⟩
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