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Article Dans Une Revue International Journal of Molecular Sciences Année : 2023

Transcriptomic study on human skin samples: Identification of two subclasses of actinic keratoses

Résumé

Actinic keratoses (AKs) are sun-damaged skin areas that affect 20% of the European adult population and more than 50% of people aged 70 years and over. There are currently no clinical or histological features allowing us to identify to which clinical class (i.e., regression or progression) an AK belongs. A transcriptomic approach seems to be a robust tool for AK characterization, but there is a need for additional studies, including more patients and elucidating the molecular signature of an AK. In this context, the present study, including the largest number of patients to date, is the first aiming at identifying biological features to objectively distinguish different AK signatures. We highlight two distinct molecular profiles: AKs featuring a molecular profile similar to squamous cell carcinomas (SCCs), which are called “lesional AKs” (AK_Ls), and AKs featuring a molecular profile similar to normal skin tissue, which are called “non-lesional AKs” (AK_NLs). The molecular profiles of both AK subclasses were studied, and 316 differentially expressed genes (DEGs) were identified between the two classes. The 103 upregulated genes in AK_L were related to the inflammatory response. Interestingly, downregulated genes were associated with keratinization. Finally, based on a connectivity map approach, our data highlight that the VEGF pathway could be a promising therapeutic target for high-risk lesions.
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hal-04039220 , version 1 (25-10-2023)

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Hélène Dubois-Pot-Schneider, Grégoire Khairallah, Cyril Brzenczek, François Plénat, Frédéric Marchal, et al.. Transcriptomic study on human skin samples: Identification of two subclasses of actinic keratoses. International Journal of Molecular Sciences, 2023, Looking into the Skin in Health and Disease: From Microscopy Imaging Techniques to Molecular Analysis, 24 (6), pp.5937. ⟨10.3390/ijms24065937⟩. ⟨hal-04039220⟩
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