Circulating Tumor Cell cluster phenotype allows monitoring response to treatment and predicts survival - CNRS - Centre national de la recherche scientifique
Article Dans Une Revue Scientific Reports Année : 2019

Circulating Tumor Cell cluster phenotype allows monitoring response to treatment and predicts survival

Ajay Balakrishnan
  • Fonction : Auteur
Deepak Koppaka
  • Fonction : Auteur
Abhishek Anand
  • Fonction : Auteur
Barnali Deb
  • Fonction : Auteur
Gianluca Grenci
Virgile Viasnoff
Erik Thompson
Harsha Gowda
Ramray Bhat
  • Fonction : Auteur
Annapoorni Rangarajan
  • Fonction : Auteur
Jean Paul Thiery
K. Govind Babu
  • Fonction : Auteur
Prashant Kumar
  • Fonction : Auteur

Résumé

Abstract Circulating tumor cells (CTCs) are putative markers of tumor prognosis and may serve to evaluate patient’s response to chemotherapy. CTCs are often detected as single cells but infrequently as clusters and are indicative of worse prognosis. In this study, we developed a short-term culture of nucleated blood cells which was applied to blood samples from breast, lung, esophageal and bladder cancer patients. Clusters of different degrees of compactness, classified as very tight, tight and loose were observed across various cancer types. These clusters show variable expression of cytokeratins. Cluster formation from blood samples obtained during the course of chemotherapy was found to be associated with disease progression and shorter overall survival. The short-term cultures offer a robust and highly reliable method for early prediction of treatment response in different cancer types.

Dates et versions

hal-04078739 , version 1 (24-04-2023)

Identifiants

Citer

Ajay Balakrishnan, Deepak Koppaka, Abhishek Anand, Barnali Deb, Gianluca Grenci, et al.. Circulating Tumor Cell cluster phenotype allows monitoring response to treatment and predicts survival. Scientific Reports, 2019, 9 (1), pp.7933. ⟨10.1038/s41598-019-44404-y⟩. ⟨hal-04078739⟩
10 Consultations
0 Téléchargements

Altmetric

Partager

More