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Journal Articles (Review Article) Frontiers in Cell and Developmental Biology Year : 2023

Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity

Abstract

Cancer cell heterogeneity is a key contributor to therapeutic failure and posttreatment recurrence. Targeting cell subpopulations responsible for chemoresistance and recurrence seems to be an attractive approach to improve treatment outcome in cancer patients. However, this remains challenging due to the complexity and incomplete characterization of tumor cell subpopulations. The heterogeneity of cells exhibiting stemness-related features, such as self-renewal and chemoresistance, fuels this complexity. Notch signaling is a known regulator of cancer stem cell (CSC) features in colorectal cancer (CRC), though the effects of its heterogenous signaling on CRC cell stemness are only just emerging. In this review, we discuss how Notch ligand-receptor specificity contributes to regulating stemness, self-renewal, chemoresistance and cancer stem cells heterogeneity in CRC.
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hal-04275449 , version 1 (08-11-2023)

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Morgan Brisset, Patrick Mehlen, Olivier Meurette, Frédéric Hollande. Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity. Frontiers in Cell and Developmental Biology, 2023, 11, pp.1231416. ⟨10.3389/fcell.2023.1231416⟩. ⟨hal-04275449⟩
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