Redox-Based Strategies against Infections by Eukaryotic Pathogens - CNRS - Centre national de la recherche scientifique Access content directly
Journal Articles Genes Year : 2023

Redox-Based Strategies against Infections by Eukaryotic Pathogens


Redox homeostasis is an equilibrium between reducing and oxidizing reactions within cells. It is an essential, dynamic process, which allows proper cellular reactions and regulates biological responses. Unbalanced redox homeostasis is the hallmark of many diseases, including cancer or inflammatory responses, and can eventually lead to cell death. Specifically, disrupting redox balance, essentially by increasing pro-oxidative molecules and favouring hyperoxidation, is a smart strategy to eliminate cells and has been used for cancer treatment, for example. Selectivity between cancer and normal cells thus appears crucial to avoid toxicity as much as possible. Redoxbased approaches are also employed in the case of infectious diseases to tackle the pathogens specifically, with limited impacts on host cells. In this review, we focus on recent advances in redoxbased strategies to fight eukaryotic pathogens, especially fungi and eukaryotic parasites. We report molecules recently described for causing or being associated with compromising redox homeostasis in pathogens and discuss therapeutic possibilities.
Fichier principal
Vignette du fichier
2023 genes-14-00778.pdf (454.03 Ko) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

hal-04276336 , version 1 (08-11-2023)



Cindy Vallières, Marie-Pierre Golinelli-Cohen, Olivier Guittet, Michel Lepoivre, Meng-Er Huang, et al.. Redox-Based Strategies against Infections by Eukaryotic Pathogens. Genes, 2023, 14 (4), ⟨10.3390/genes14040778⟩. ⟨hal-04276336⟩
25 View
6 Download



Gmail Mastodon Facebook X LinkedIn More