Let $D$ be a simple derivation of the polynomial ring $\mathbb{k}[x_1,\dots,x_n]$, where $\mathbb{k}$ is an algebraically closed field of characteristic zero, and denote by $\operatorname{Aut}(D)\subset\operatorname{Aut}(\mathbb{k}[x_1,\dots,x_n])$ the subgroup of $\mathbb{k}$-automorphisms commuting with $D$. We show that the connected component of $\operatorname{Aut}(D)$ passing through the identity is a unipotent algebraic group of dimension at most $n-2$, this bound being sharp. Moreover, $\operatorname{Aut}(D)$ is an algebraic group if and only if it is a connected ind-group. Given a simple derivation $D$, we characterize when $\operatorname{Aut}(D)$ contains a normal subgroup of translations. As an application of our techniques we show that if $n=3$, then either $\operatorname{Aut}(D)$ is a discrete group or it is isomorphic to the additive group acting by translations, and give some insight on the case $n=4$.