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Article Dans Une Revue Journal of Cell Biology Année : 2007

Pericentric heterochromatin reprogramming by new histone variants during mouse spermiogenesis.

Résumé

During male germ cell postmeiotic maturation, dramatic chromatin reorganization occurs, which is driven by completely unknown mechanisms. For the first time, we describe a specific reprogramming of mouse pericentric heterochromatin. Initiated when histones undergo global acetylation in early elongating spermatids, this process leads to the establishment of new DNA packaging structures organizing the pericentric regions in condensing spermatids. Five new histone variants were discovered, which are expressed in late spermiogenic cells. Two of them, which we named H2AL1 and H2AL2, specifically mark the pericentric regions in condensing spermatids and participate in the formation of new nucleoprotein structures. Moreover, our investigations also suggest that TH2B, an already identified testis-specific H2B variant of unknown function, could provide a platform for the structural transitions accompanying the incorporation of these new histone variants.

Domaines

Cancer

Dates et versions

inserm-00176730 , version 1 (04-10-2007)

Identifiants

Citer

Jérôme Govin, Emmanuelle Escoffier, Sophie Rousseaux, Lauriane Kuhn, Myriam Ferro, et al.. Pericentric heterochromatin reprogramming by new histone variants during mouse spermiogenesis.. Journal of Cell Biology, 2007, 176 (3), pp.283-94. ⟨10.1083/jcb.200604141⟩. ⟨inserm-00176730⟩
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