UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers? - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue BMC Cancer Année : 2007

UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?

Giselle N'Koutchou
  • Fonction : Auteur
  • PersonId : 845421
Sylvie Cénée
  • Fonction : Auteur
  • PersonId : 845422
Moana Gelu-Simeon
  • Fonction : Auteur
  • PersonId : 845424
Françoise F. Degos
  • Fonction : Auteur
  • PersonId : 845426
Denis Hémon
  • Fonction : Auteur
  • PersonId : 834321
Gilles G. Pelletier
  • Fonction : Auteur
  • PersonId : 845429

Résumé

ABSTRACT: BACKGROUND: We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC). Patients and Methods The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were men younger than 75 years. HCC and cirrhosis patients were stratified according to time since cirrhosis diagnosis. RESULTS: We found a positive association between the UGT1A7*3/*3 genotype and HCC when the comparison was restricted to patients whose disease was of viral origin [OR=3.4 (0.3-45)] but a negative association when it included only alcoholic patients [OR=0.1 (0.02-0.6)]. CONCLUSION: Our study shows that UGT1A7 may play a role in hepatocellular carcinogenesis and that this role may differ according to the primary cause of the cirrhosis.
Fichier principal
Vignette du fichier
StuckerI_2007.pdf (220.06 Ko) Télécharger le fichier
Loading...

Dates et versions

inserm-00198447 , version 1 (17-12-2007)

Identifiants

Citer

Isabelle Stücker, Marie-Anne Loriot, Giselle N'Koutchou, Sylvie Cénée, Laurent Bodin, et al.. UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?. BMC Cancer, 2007, 7 (1), pp.214. ⟨10.1186/1471-2407-7-214⟩. ⟨inserm-00198447⟩
156 Consultations
357 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More