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Article Dans Une Revue AIDS. Official journal of the international AIDS Society Année : 2018

Incidence of new hepatitis C virus infection is still increasing in French MSM living with HIV

1 HCL - Hospices Civils de Lyon
2 Service Universitaire des Maladies Infectieuses et du Voyageur [Tourcoing]
3 Maladies infectieuses et tropicales
4 CIC Nantes - Centre d’Investigation Clinique de Nantes
5 Service Maladies infectieuses et tropicales [CHU Toulouse]
6 CPTP - Centre de Physiopathologie Toulouse Purpan
7 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
8 Service d'immuno-hématologie clinique (CISIH)
9 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
10 Service de Maladies Infectieuses [Nice]
11 Département Maladies Infectieuses et Tropicales, Hôpital Universitaire, Montpellier, France
12 TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes
13 Service des maladies infectieuses
14 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane
15 MAITC EA 4537 - Maladies infectieuses et tropicales dans la Caraïbe
16 Unité des Maladies Infectieuses et Tropicales
17 Laboratoire de Virologie [CHU Necker]
18 Hôpital Necker - Enfants Malades [AP-HP]
19 Service des Maladies Infectieuses et Tropicales [CHU Clermont-Ferrand]
20 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
21 service de maladies infectieuses CHU J Minjoz Besancon
22 Service des maladies infectieuses et tropicales [HCL-Hôpital de la Croix Rousse]
23 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
David Rey
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  • PersonId : 879525
Bruno Hoen

Résumé

OBJECTIVE: High hepatitis C virus (HCV) treatment uptake combined with effective direct-acting antiviral-based regimens resulted in a dramatic decline of HCV infection in French people living with HIV (PLWH). We assessed the yearly incidence of new HCV infection in PLWH enrolled in the large French Dat'AIDS cohort from 2012 to 2016 with a specific focus on MSM. METHODS: The incidence of new HCV infection was determined yearly in HCV-negative PLWH with serological follow-up during 2012-2016. The incidence of HCV reinfection was determined in patients who were cured of a previous infection. RESULTS: Among 40 714 PLWH, HCV status was available in 38 217 (94%). A total of 5557 PLWH (15%) were HCV infected at first time-point, 82% of whom were cured of HCV by the end of 2016. Among 21 519 HCV-negative PLWH with serological follow-up (63 449 patient-years), 219 first HCV infections occurred (MSM: 188, others: 31). Similarly, among 3406 patients who were cured of a previous infection (10 602 patient-years), 73 reinfections occurred (MSM: 51, others: 22). From 2012 to 2016, the incidence of a first infection in MSM rose from 0.5 to 0.92% patient-years, whereas the incidence or reinfection remained stable (2.52-2.90% patient-years). CONCLUSION: Despite a high HCV treatment uptake and cure rate, the incidence of first HCV infection regularly increased in French HIV-positive MSM between 2012 and 2016. The incidence of reinfection fluctuated but remained constantly higher than the incidence of first infection, suggesting that a subgroup of MSM pursued high-risk practices following cure of a first infection.
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Dates et versions

inserm-02101081 , version 1 (16-04-2019)

Identifiants

Citer

Pierre Pradat, Thomas Huleux, François Raffi, Pierre Delobel, Antoine Valantin, et al.. Incidence of new hepatitis C virus infection is still increasing in French MSM living with HIV. AIDS. Official journal of the international AIDS Society, 2018, 32 (8), pp.1077-1082. ⟨10.1097/QAD.0000000000001789⟩. ⟨inserm-02101081⟩
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