The E3 ubiquitin ligase TRIP12 participates in cell cycle progression and chromosome stability - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2020

The E3 ubiquitin ligase TRIP12 participates in cell cycle progression and chromosome stability

Résumé

Several studies have linked the E3 ubiquitin ligase TRIP12 (Thyroid hormone Receptor Interacting Protein 12) to the cell cycle. However, the regulation and the implication of this protein during the cell cycle are largely unknown. In this study, we show that TRIP12 expression is regulated during the cell cycle, which correlates with its nuclear localization. We identify an euchromatin-binding function of TRIP12 mediated by a N-terminal intrinsically disordered region. We demonstrate the functional implication of TRIP12 in the mitotic entry by controlling the duration of DNA replication that is independent from its catalytic activity. We also show the requirement of TRIP12 in the mitotic progression and chromosome stability. Altogether, our findings show that TRIP12 is as a new chromatin-associated protein with several implications in the cell cycle progression and in the maintenance of genome integrity.
Fichier principal
Vignette du fichier
s41598-020-57762-9.pdf (2.58 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

inserm-02489315 , version 1 (24-02-2020)

Licence

Paternité

Identifiants

Citer

Dorian Larrieu, Manon Brunet, Claire Vargas, Naïma Hanoun, Laetitia Ligat, et al.. The E3 ubiquitin ligase TRIP12 participates in cell cycle progression and chromosome stability. Scientific Reports, 2020, 10 (1), pp.789. ⟨10.1038/s41598-020-57762-9⟩. ⟨inserm-02489315⟩
128 Consultations
84 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More