Two-step strategy for the identification of SARS-CoV-2 variant of concern 202012/01 and other variants with spike deletion H69–V70, France, August to December 2020 - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Eurosurveillance Année : 2021

Two-step strategy for the identification of SARS-CoV-2 variant of concern 202012/01 and other variants with spike deletion H69–V70, France, August to December 2020

Résumé

We report the strategy leading to the first detection of variant of concern 202012/01 (VOC) in France (21 December 2020). First, the spike (S) deletion H69-V70 (ΔH69/ΔV70), identified in certain SARS-CoV-2 variants including VOC, is screened for. This deletion is associated with a S-gene target failure (SGTF) in the three-target RT-PCR assay (TaqPath kit). Subsequently, SGTF samples are whole genome sequenced. This approach revealed mutations co-occurring with ΔH69/ΔV70 including S:N501Y in the VOC.
Fichier principal
Vignette du fichier
Bal et al. - 2021 - Two-step strategy for the identification of SARS-C.pdf (228.25 Ko) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

inserm-03412069 , version 1 (02-11-2021)

Identifiants

Citer

Antonin Bal, Gregory Destras, Alexandre Gaymard, Karl Stefic, Julien Marlet, et al.. Two-step strategy for the identification of SARS-CoV-2 variant of concern 202012/01 and other variants with spike deletion H69–V70, France, August to December 2020. Eurosurveillance, 2021, 26 (3), pp.2100008. ⟨10.2807/1560-7917.es.2021.26.3.2100008⟩. ⟨inserm-03412069⟩
47 Consultations
51 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More