Major depression and heart failure: Interest of monoamine oxidase inhibitors - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue International Journal of Cardiology Année : 2017

Major depression and heart failure: Interest of monoamine oxidase inhibitors

Résumé

Several physiopathological hypotheses have been studied to explain the link between heart failure (HF) and major depression (MD). An increase of monoamine oxidase (MAO) has recently been found as a factor involved in the development of HF. The aim of this review is to provide a complete overview of the involvement of MAOs in HF comorbidity of MD and to discuss the pharmacological options. Our work highlights the scientific evidence of MAO involvement in the development of HF. Studies focusing on MAO-A seem to have reproducible results on HF, establishing the effect of this enzyme as well as the protective effect of its inhibition. Fewer studies addressed MAO-B; results are nonetheless encouraging. Based on this knowledge, the hypothesis of a rise of MAO activity in HF seems to be well established. The large prevalence of comorbid MD in HF could be due to the deamination of monoamines linked with MAOs activity. In addition, MAOIs are effective in MD and well tolerated among the elderly according to the literature. This original hypothesis provides a new perspective in the use of MAOIs in HF patients with MD.
Fichier non déposé

Dates et versions

inserm-03904095 , version 1 (13-09-2023)

Identifiants

Citer

Sophie Corbineau, Marie Breton, Jeanne Mialet-Perez, Jean-François Costemale-Lacoste. Major depression and heart failure: Interest of monoamine oxidase inhibitors. International Journal of Cardiology, 2017, 247, pp.1-6. ⟨10.1016/j.ijcard.2017.07.005⟩. ⟨inserm-03904095⟩
11 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More