DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Journal of Experimental Medicine Année : 2003

DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells.

Résumé

Early interactions between lung dendritic cells (LDCs) and Mycobacterium tuberculosis, the etiological agent of tuberculosis, are thought to be critical for mounting a protective anti-mycobacterial immune response and for determining the outcome of infection. However, these interactions are poorly understood, at least at the molecular level. Here we show that M. tuberculosis enters human monocyte-derived DCs after binding to the recently identified lectin DC-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN). By contrast, complement receptor (CR)3 and mannose receptor (MR), which are the main M. tuberculosis receptors on macrophages (Mphis), appeared to play a minor role, if any, in mycobacterial binding to DCs. The mycobacteria-specific lipoglycan lipoarabinomannan (LAM) was identified as a key ligand of DC-SIGN. Freshly isolated human LDCs were found to express DC-SIGN, and M. tuberculosis-derived material was detected in CD14(-)HLA-DR(+)DC-SIGN(+) cells in lymph nodes (LNs) from patients with tuberculosis. Thus, as for human immunodeficiency virus (HIV), which is captured by the same receptor, DC-SIGN-mediated entry of M. tuberculosis in DCs in vivo is likely to influence bacterial persistence and host immunity.
Fichier principal
Vignette du fichier
121.full.pdf (284.5 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

pasteur-01372712 , version 1 (27-09-2016)

Identifiants

Citer

Ludovic Tailleux, Olivier Schwartz, Jean-Louis Herrmann, Elisabeth Pivert, Mary Jackson, et al.. DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells.. Journal of Experimental Medicine, 2003, 197 (1), pp.121-7. ⟨10.1084/jem.20021468⟩. ⟨pasteur-01372712⟩
210 Consultations
263 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More